tag:blogger.com,1999:blog-19951012112806347102011-04-21T14:25:37.037-07:00dimkohttp://www.blogger.com/profile/06452544989556534131noreply@blogger.comBlogger11100tag:blogger.com,1999:blog-1995101211280634710.post-33369224498268933752009-01-21T15:24:00.000-08:002009-01-21T15:30:03.295-08:00Amoxicillin is recommended for anthrax prevention in pregnancy. The objective of this study was to evaluate the pharmacokinetics of amoxicillin during pregnancy and postpartum (PP). Sixteen women received amoxicillin during gestation (18–22 weeks (T2) and 30–34 weeks (T3)) as well as 3 months postpartum (PP) to evaluate single-dose pharmacokinetics. Amoxicillin compartmental pharmacokinetic parameters were used to simulate amoxicillin concentration–time profiles following different dosage strategies. Amoxicillin CL_renal (T2: 24.8<img src="http://www.nature.com/__chars/plus/special/plusmn/black/med/base/glyph.gif" style="border: 0pt none ; vertical-align: baseline;" alt="plusminus" />6.7 l/h, <i>P</i><0.001; src="http://www.nature.com/__chars/plus/special/plusmn/black/med/base/glyph.gif" style="border: 0pt none ; vertical-align: baseline;" alt="plusminus">3.9 l/h, <i>P</i><0.001; src="http://www.nature.com/__chars/plus/special/plusmn/black/med/base/glyph.gif" style="border: 0pt none ; vertical-align: baseline;" alt="plusminus">2.6 l/h) and renal CL_secretion (T2: 280<img src="http://www.nature.com/__chars/plus/special/plusmn/black/med/base/glyph.gif" style="border: 0pt none ; vertical-align: baseline;" alt="plusminus" />105 ml/min, <i>P</i><0.002; src="http://www.nature.com/__chars/plus/special/plusmn/black/med/base/glyph.gif" style="border: 0pt none ; vertical-align: baseline;" alt="plusminus">54 ml/min, <i>P</i><0.001; src="http://www.nature.com/__chars/plus/special/plusmn/black/med/base/glyph.gif" style="border: 0pt none ; vertical-align: baseline;" alt="plusminus">47 ml/min) were higher during pregnancy than postpartum. Simulations suggest that amoxicillin concentrations adequate to prevent anthrax may be difficult to achieve during pregnancy and postpartum. Increases in amoxicillin CL_renal and renal CL_secretion reflect increases in filtration and secretory transport or diminished reabsorption in the kidneys. 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